Drug interactions
Epcoritamab + Ergotamine
Severity: Major
Epcoritamab and Ergotamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab releases cytokines that can temporarily suppress CYP enzyme activity. This may raise ergotamine levels and the risk of vasospasm and ischemia.
What this interaction means in plain words
Epcoritamab and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Epcoritamab belongs to Oncology; Ergotamine belongs to Central Nervous System.
Why it happens
Cytokine-mediated downregulation of CYP3A4 reduces ergotamine metabolism.
What to do
Avoid ergotamine around the time of epcoritamab step-up dosing and during cytokine release syndrome. If it is unavoidable, monitor closely for ergotism and use the lowest effective ergotamine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
- Cyclosporin + Epcoritamab Moderate
Frequently asked questions
Can I take Epcoritamab with Ergotamine?
MediHelp rates the interaction as major. Epcoritamab and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Epcoritamab releases cytokines that can temporarily suppress CYP enzyme activity. This may raise ergotamine levels and the risk of vasospasm and ischemia.
How serious is the interaction between Epcoritamab and Ergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ergotamine around the time of epcoritamab step-up dosing and during cytokine release syndrome. If it is unavoidable, monitor closely for ergotism and use the lowest effective ergotamine dose.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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