Drug interactions
Carbamazepine + Epcoritamab
Severity: Moderate
Carbamazepine and Epcoritamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cytokine release caused by epcoritamab can temporarily suppress CYP activity and raise carbamazepine concentrations. As carbamazepine has a narrow therapeutic range, toxicity may occur.
What this interaction means in plain words
Carbamazepine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carbamazepine belongs to Central Nervous System; Epcoritamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 during cytokine release syndrome.
What to do
Monitor for carbamazepine toxicity and consider checking levels at the start of treatment and during cytokine release. Adjust the dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
- Cyclosporin + Epcoritamab Moderate
Frequently asked questions
Can I take Carbamazepine with Epcoritamab?
MediHelp rates the interaction as moderate. Carbamazepine and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cytokine release caused by epcoritamab can temporarily suppress CYP activity and raise carbamazepine concentrations. As carbamazepine has a narrow therapeutic range, toxicity may occur.
How serious is the interaction between Carbamazepine and Epcoritamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for carbamazepine toxicity and consider checking levels at the start of treatment and during cytokine release. Adjust the dose as needed.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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