Drug interactions
Cyclosporin + Epcoritamab
Severity: Moderate
Cyclosporin and Epcoritamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Epcoritamab induces cytokine release that can temporarily suppress CYP450 enzymes. Cyclosporine exposure may therefore increase, raising the risk of nephrotoxicity, hypertension and neurotoxicity. The effect is most likely around cytokine release syndrome episodes.
What this interaction means in plain words
Cyclosporin and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyclosporin belongs to Miscellaneous; Epcoritamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity decreases cyclosporine clearance.
What to do
Monitor cyclosporine trough levels and renal function when starting epcoritamab and during CRS. Adjust the cyclosporine dose according to levels and toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cyclosporin
- Adenovirus types 4 and 7 live + Cyclosporin Contraindicated
- Aliskiren + Cyclosporin Contraindicated
- Bcg vaccine live + Cyclosporin Contraindicated
- Bosentan + Cyclosporin Contraindicated
- Cidofovir + Cyclosporin Contraindicated
- Cyclosporin + Dengue vaccine Contraindicated
Other interactions of Epcoritamab
- Epcoritamab + Ergotamine Major
- Epcoritamab + Pimozide Major
- Bendamustine + Epcoritamab Moderate
- Carbamazepine + Epcoritamab Moderate
- Clomipramine + Epcoritamab Moderate
- Clozapine + Epcoritamab Moderate
Frequently asked questions
Can I take Cyclosporin with Epcoritamab?
MediHelp rates the interaction as moderate. Cyclosporin and Epcoritamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Epcoritamab induces cytokine release that can temporarily suppress CYP450 enzymes. Cyclosporine exposure may therefore increase, raising the risk of nephrotoxicity, hypertension and neurotoxicity. The effect is most likely around cytokine release syndrome episodes.
How serious is the interaction between Cyclosporin and Epcoritamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cyclosporine trough levels and renal function when starting epcoritamab and during CRS. Adjust the cyclosporine dose according to levels and toxicity.
What other medicines interact with Cyclosporin?
MediHelp also lists interactions of Cyclosporin with, for example, Adenovirus types 4 and 7 live, Aliskiren, Bcg vaccine live. The full list is on the Cyclosporin page.
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