Drug interactions
Bendamustine + Fostamatinib
Severity: Minor
Bendamustine and Fostamatinib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and could raise exposure to P-gp substrates. Bendamustine is not a well-established clinically sensitive P-gp substrate, so any increase in toxicity such as myelosuppression is theoretical.
What this interaction means in plain words
Bendamustine and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Fostamatinib belongs to Oncology.
Why it happens
Possible inhibition of intestinal and cellular P-gp efflux by the fostamatinib metabolite tamatinib, which may modestly raise bendamustine exposure.
What to do
No dose change is generally needed; monitor blood counts as routinely done during bendamustine therapy and reassess if unexpected cytopenias occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bendamustine
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
Frequently asked questions
Can I take Bendamustine with Fostamatinib?
MediHelp rates the interaction as minor. Bendamustine and Fostamatinib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Fostamatinib's active metabolite inhibits P-glycoprotein and could raise exposure to P-gp substrates. Bendamustine is not a well-established clinically sensitive P-gp substrate, so any increase in toxicity such as myelosuppression is theoretical.
How serious is the interaction between Bendamustine and Fostamatinib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor blood counts as routinely done during bendamustine therapy and reassess if unexpected cytopenias occur.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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