Drug interactions
Amobarbital + Fostamatinib
Severity: Moderate
Amobarbital and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Amobarbital may reduce exposure to the active metabolite of fostamatinib through CYP3A4 induction. This could lead to loss of platelet-raising effect in immune thrombocytopenia. Labeling for fostamatinib notes reduced exposure with strong CYP3A4 inducers.
What this interaction means in plain words
Amobarbital and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Amobarbital belongs to Central Nervous System; Fostamatinib belongs to Oncology.
Why it happens
Induction of CYP3A4 by amobarbital increases clearance of fostamatinib's active metabolite R406.
What to do
Monitor platelet counts and clinical response, and consider an alternative to amobarbital. Adjust the fostamatinib dose according to response if the inducer must continue.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Amobarbital
- Amobarbital + Calcium / magnesium / potassium / sodium oxybates Contraindicated
- Amobarbital + Doravirine Contraindicated
- Amobarbital + Elbasvir / grazoprevir Contraindicated
- Amobarbital + Isavuconazonium Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amobarbital + Lonafarnib Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
- Carbamazepine + Fostamatinib Moderate
Frequently asked questions
Can I take Amobarbital with Fostamatinib?
MediHelp rates the interaction as moderate. Amobarbital and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Amobarbital may reduce exposure to the active metabolite of fostamatinib through CYP3A4 induction. This could lead to loss of platelet-raising effect in immune thrombocytopenia. Labeling for fostamatinib notes reduced exposure with strong CYP3A4 inducers.
How serious is the interaction between Amobarbital and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and clinical response, and consider an alternative to amobarbital. Adjust the fostamatinib dose according to response if the inducer must continue.
What other medicines interact with Amobarbital?
MediHelp also lists interactions of Amobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Amobarbital page.
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