Drug interactions
Colchicine + Fostamatinib
Severity: Major
Colchicine and Fostamatinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-glycoprotein and may increase colchicine concentrations. Higher exposure raises the risk of colchicine toxicity, particularly with kidney or liver impairment.
What this interaction means in plain words
Colchicine and Fostamatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Colchicine belongs to Genitourinary; Fostamatinib belongs to Oncology.
Why it happens
Tamatinib inhibits P-gp efflux, raising colchicine exposure.
What to do
Avoid in renal or hepatic impairment. Otherwise consider reducing the colchicine dose and monitor for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Colchicine
- Clarithromycin + Colchicine Contraindicated
- Cobicistat + Colchicine Contraindicated
- Colchicine + Cyclosporine Contraindicated
- Colchicine + Ensitrelvir Contraindicated
- Colchicine + Levoketoconazole Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
Other interactions of Fostamatinib
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
- Carbamazepine + Fostamatinib Moderate
Frequently asked questions
Can I take Colchicine with Fostamatinib?
MediHelp rates the interaction as major. Colchicine and Fostamatinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fostamatinib's active metabolite inhibits P-glycoprotein and may increase colchicine concentrations. Higher exposure raises the risk of colchicine toxicity, particularly with kidney or liver impairment.
How serious is the interaction between Colchicine and Fostamatinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in renal or hepatic impairment. Otherwise consider reducing the colchicine dose and monitor for toxicity.
What other medicines interact with Colchicine?
MediHelp also lists interactions of Colchicine with, for example, Clarithromycin, Cobicistat, Cyclosporine. The full list is on the Colchicine page.
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