Drug interactions
Apalutamide + Fostamatinib
Severity: Moderate
Apalutamide and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Apalutamide may decrease exposure to R406, the active metabolite of fostamatinib, which may reduce platelet-raising efficacy in immune thrombocytopenia.
What this interaction means in plain words
Apalutamide and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Apalutamide belongs to Endocrine; Fostamatinib belongs to Oncology.
Why it happens
Apalutamide induces CYP3A4, which metabolizes R406.
What to do
Monitor platelet counts and consider a fostamatinib dose increase per labeling if response is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Apalutamide
- Apalutamide + Cabotegravir Contraindicated
- Apalutamide + Cobicistat Contraindicated
- Apalutamide + Doravirine Contraindicated
- Apalutamide + Elbasvir / grazoprevir Contraindicated
- Apalutamide + Ensitrelvir Contraindicated
- Apalutamide + Fostemsavir Contraindicated
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Atorvastatin + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
- Carbamazepine + Fostamatinib Moderate
Frequently asked questions
Can I take Apalutamide with Fostamatinib?
MediHelp rates the interaction as moderate. Apalutamide and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Apalutamide may decrease exposure to R406, the active metabolite of fostamatinib, which may reduce platelet-raising efficacy in immune thrombocytopenia.
How serious is the interaction between Apalutamide and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor platelet counts and consider a fostamatinib dose increase per labeling if response is lost.
What other medicines interact with Apalutamide?
MediHelp also lists interactions of Apalutamide with, for example, Cabotegravir, Cobicistat, Doravirine. The full list is on the Apalutamide page.
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