Drug interactions
Atorvastatin + Fostamatinib
Severity: Moderate
Atorvastatin and Fostamatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fostamatinib's active metabolite inhibits P-gp and BCRP and can raise atorvastatin exposure. Higher exposure increases the risk of statin-related muscle toxicity.
What this interaction means in plain words
Atorvastatin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Atorvastatin belongs to Cardiovascular; Fostamatinib belongs to Oncology.
Why it happens
Tamatinib inhibits intestinal P-gp and BCRP, increasing atorvastatin absorption.
What to do
Monitor for myalgia and consider reducing the atorvastatin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Atorvastatin
- Atorvastatin + Tipranavir Contraindicated
- Atazanavir + Atorvastatin Major
- Atorvastatin + Clarithromycin Major
- Atorvastatin + Cobicistat Major
- Atorvastatin + Cyclosporin Major
- Atorvastatin + Cyclosporine Major
Other interactions of Fostamatinib
- Colchicine + Fostamatinib Major
- Fostamatinib + Phenytoin Major
- Amobarbital + Fostamatinib Moderate
- Apalutamide + Fostamatinib Moderate
- Bosentan + Fostamatinib Moderate
- Carbamazepine + Fostamatinib Moderate
Frequently asked questions
Can I take Atorvastatin with Fostamatinib?
MediHelp rates the interaction as moderate. Atorvastatin and Fostamatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fostamatinib's active metabolite inhibits P-gp and BCRP and can raise atorvastatin exposure. Higher exposure increases the risk of statin-related muscle toxicity.
How serious is the interaction between Atorvastatin and Fostamatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for myalgia and consider reducing the atorvastatin dose if symptoms occur.
What other medicines interact with Atorvastatin?
MediHelp also lists interactions of Atorvastatin with, for example, Tipranavir, Atazanavir, Clarithromycin. The full list is on the Atorvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
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