Drug interactions
Bendamustine + Glofitamab
Severity: Moderate
Bendamustine and Glofitamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab induces cytokine release, which can transiently suppress CYP450 activity, particularly around the first doses. Bendamustine is partly metabolized by CYP1A2 to minor active metabolites, so exposure to these may change, although the clinical effect is uncertain.
What this interaction means in plain words
Bendamustine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Bendamustine belongs to Oncology; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated downregulation of CYP1A2 during cytokine release syndrome may reduce bendamustine metabolism.
What to do
Monitor for bendamustine toxicity such as myelosuppression and infections, especially during glofitamab initiation and any cytokine release syndrome episodes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Bendamustine
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
- Cyclosporin + Glofitamab Moderate
Frequently asked questions
Can I take Bendamustine with Glofitamab?
MediHelp rates the interaction as moderate. Bendamustine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab induces cytokine release, which can transiently suppress CYP450 activity, particularly around the first doses. Bendamustine is partly metabolized by CYP1A2 to minor active metabolites, so exposure to these may change, although the clinical effect is uncertain.
How serious is the interaction between Bendamustine and Glofitamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bendamustine toxicity such as myelosuppression and infections, especially during glofitamab initiation and any cytokine release syndrome episodes.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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