Drug interactions
Glofitamab + Pimozide
Severity: Major
Glofitamab and Pimozide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab causes cytokine release that may transiently suppress CYP450 enzymes and increase exposure to CYP3A4 substrates. Higher pimozide levels increase the risk of QT prolongation and serious ventricular arrhythmias.
What this interaction means in plain words
Glofitamab and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glofitamab belongs to Oncology; Pimozide belongs to Central Nervous System.
Why it happens
Cytokine-mediated suppression of CYP3A4 activity during cytokine release reduces pimozide clearance.
What to do
Monitor ECG/QTc and for pimozide toxicity during the initial dosing period and any cytokine release syndrome. Consider reducing or holding pimozide, or using an alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
- Cyclosporin + Glofitamab Moderate
Frequently asked questions
Can I take Glofitamab with Pimozide?
MediHelp rates the interaction as major. Glofitamab and Pimozide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glofitamab causes cytokine release that may transiently suppress CYP450 enzymes and increase exposure to CYP3A4 substrates. Higher pimozide levels increase the risk of QT prolongation and serious ventricular arrhythmias.
How serious is the interaction between Glofitamab and Pimozide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG/QTc and for pimozide toxicity during the initial dosing period and any cytokine release syndrome. Consider reducing or holding pimozide, or using an alternative.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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