Drug interactions
Clomipramine + Glofitamab
Severity: Moderate
Clomipramine and Glofitamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab induces cytokine release that can transiently suppress CYP enzyme activity, which may raise levels of drugs metabolized by CYP1A2, such as clomipramine. The effect is greatest after the first doses and during cytokine release syndrome.
What this interaction means in plain words
Clomipramine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clomipramine belongs to Central Nervous System; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP enzymes, including CYP1A2, reduces clomipramine metabolism.
What to do
Monitor for tricyclic toxicity such as anticholinergic effects, sedation and arrhythmia during the initial treatment cycles. Reduce the clomipramine dose if signs of toxicity appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Clomipramine
- Arsenic trioxide + Clomipramine Contraindicated
- Clomipramine + Dofetilide Contraindicated
- Clomipramine + Droperidol Contraindicated
- Clomipramine + Isocarboxazid Contraindicated
- Clomipramine + Methylene blue Contraindicated
- Clomipramine + Pentamidine Contraindicated
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
- Cyclosporin + Glofitamab Moderate
Frequently asked questions
Can I take Clomipramine with Glofitamab?
MediHelp rates the interaction as moderate. Clomipramine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab induces cytokine release that can transiently suppress CYP enzyme activity, which may raise levels of drugs metabolized by CYP1A2, such as clomipramine. The effect is greatest after the first doses and during cytokine release syndrome.
How serious is the interaction between Clomipramine and Glofitamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic toxicity such as anticholinergic effects, sedation and arrhythmia during the initial treatment cycles. Reduce the clomipramine dose if signs of toxicity appear.
What other medicines interact with Clomipramine?
MediHelp also lists interactions of Clomipramine with, for example, Arsenic trioxide, Dofetilide, Droperidol. The full list is on the Clomipramine page.
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