Drug interactions
Ergotamine + Glofitamab
Severity: Major
Ergotamine and Glofitamab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab induces cytokine release that may transiently suppress CYP3A4 activity. Ergotamine exposure may rise, raising the risk of ergotism and ischemia.
What this interaction means in plain words
Ergotamine and Glofitamab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Ergotamine belongs to Central Nervous System; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated suppression of CYP3A4 reduces ergotamine clearance.
What to do
Avoid ergotamine during the first cycles of glofitamab and during cytokine release syndrome. If unavoidable, monitor for vasospastic symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Other interactions of Glofitamab
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Clozapine + Glofitamab Moderate
- Cyclosporin + Glofitamab Moderate
Frequently asked questions
Can I take Ergotamine with Glofitamab?
MediHelp rates the interaction as major. Ergotamine and Glofitamab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Glofitamab induces cytokine release that may transiently suppress CYP3A4 activity. Ergotamine exposure may rise, raising the risk of ergotism and ischemia.
How serious is the interaction between Ergotamine and Glofitamab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid ergotamine during the first cycles of glofitamab and during cytokine release syndrome. If unavoidable, monitor for vasospastic symptoms.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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