Drug interactions
Clozapine + Glofitamab
Severity: Moderate
Clozapine and Glofitamab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glofitamab triggers cytokine release, and raised cytokines such as IL-6 can suppress CYP450 enzymes, including CYP1A2. Clozapine levels may therefore rise, particularly around the first doses or during cytokine release syndrome, increasing the risk of sedation, seizures, hypotension and other clozapine toxicity.
What this interaction means in plain words
Clozapine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Clozapine belongs to Central Nervous System; Glofitamab belongs to Oncology.
Why it happens
Cytokine-mediated transient suppression of CYP1A2 reduces clozapine clearance.
What to do
Monitor for clozapine toxicity (sedation, hypotension, seizures) during the first cycle and any cytokine release syndrome episodes. Consider checking clozapine concentrations and reducing the dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Clozapine and Glofitamab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Clozapine
- Clozapine + Deferiprone Contraindicated
- Clozapine + Irinotecan Contraindicated
- Clozapine + Pimozide Contraindicated
- Clozapine + Thioridazine Contraindicated
- Acalabrutinib + Clozapine Major
- Adagrasib + Clozapine Major
Other interactions of Glofitamab
- Ergotamine + Glofitamab Major
- Glofitamab + Pimozide Major
- Bendamustine + Glofitamab Moderate
- Carbamazepine + Glofitamab Moderate
- Clomipramine + Glofitamab Moderate
- Cyclosporin + Glofitamab Moderate
Frequently asked questions
Can I take Clozapine with Glofitamab?
MediHelp rates the interaction as moderate. Clozapine and Glofitamab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glofitamab triggers cytokine release, and raised cytokines such as IL-6 can suppress CYP450 enzymes, including CYP1A2. Clozapine levels may therefore rise, particularly around the first doses or during cytokine release syndrome, increasing the risk of sedation, seizures, hypotension and other clozapine toxicity.
How serious is the interaction between Clozapine and Glofitamab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for clozapine toxicity (sedation, hypotension, seizures) during the first cycle and any cytokine release syndrome episodes. Consider checking clozapine concentrations and reducing the dose if toxicity appears.
What other medicines interact with Clozapine?
MediHelp also lists interactions of Clozapine with, for example, Deferiprone, Irinotecan, Pimozide. The full list is on the Clozapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
