Drug interactions
Bendamustine + Rucaparib
Severity: Minor
Bendamustine and Rucaparib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rucaparib inhibits CYP1A2 in vitro, and bendamustine is partly cleared through CYP1A2 into active metabolites. Exposure to the parent drug may rise and exposure to its active metabolites may fall, though the clinical effect is uncertain.
What this interaction means in plain words
Bendamustine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bendamustine belongs to Oncology; Rucaparib belongs to Oncology.
Why it happens
Rucaparib is a moderate CYP1A2 inhibitor and may reduce CYP1A2-mediated bendamustine metabolism.
What to do
No empirical dose change is needed; monitor for increased myelosuppression and adverse effects of bendamustine, especially in the first cycles.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Bendamustine
Other interactions of Rucaparib
- Cisapride + Rucaparib Major
- Ergotamine + Rucaparib Major
- Pimozide + Rucaparib Major
- Alfuzosin + Rucaparib Moderate
- Aripiprazole + Rucaparib Moderate
- Atorvastatin + Rucaparib Moderate
Frequently asked questions
Can I take Bendamustine with Rucaparib?
MediHelp rates the interaction as minor. Bendamustine and Rucaparib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rucaparib inhibits CYP1A2 in vitro, and bendamustine is partly cleared through CYP1A2 into active metabolites. Exposure to the parent drug may rise and exposure to its active metabolites may fall, though the clinical effect is uncertain.
How serious is the interaction between Bendamustine and Rucaparib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for increased myelosuppression and adverse effects of bendamustine, especially in the first cycles.
What other medicines interact with Bendamustine?
MediHelp also lists interactions of Bendamustine with, for example, Axicabtagene ciloleucel, Brexucabtagene autoleucel, Chlorambucil. The full list is on the Bendamustine page.
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