Drug interactions
Bendroflumethiazide + Digoxin
Severity: Moderate
Bendroflumethiazide and Digoxin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can cause hypokalemia and hypomagnesemia, which sensitize the heart to digoxin and increase the risk of arrhythmias and toxicity.
What this interaction means in plain words
Bendroflumethiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and hypomagnesemia enhance digoxin binding to Na+/K+-ATPase and myocardial sensitivity.
What to do
Monitor potassium and magnesium regularly and supplement as needed; check digoxin level if toxicity is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Digoxin
- Digoxin + Lily of the valley Contraindicated
- Digoxin + Squill Contraindicated
- Adagrasib + Digoxin Major
- Amiodarone + Digoxin Major
- Amlodipine-hydrochlorothiazide-valsartan + Digoxin Major
- Amphotericin b deoxycholate + Digoxin Major
Frequently asked questions
Can I take Bendroflumethiazide with Digoxin?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Digoxin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can cause hypokalemia and hypomagnesemia, which sensitize the heart to digoxin and increase the risk of arrhythmias and toxicity.
How serious is the interaction between Bendroflumethiazide and Digoxin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor potassium and magnesium regularly and supplement as needed; check digoxin level if toxicity is suspected.
What other medicines interact with Digoxin?
MediHelp also lists interactions of Digoxin with, for example, Lily of the valley, Squill, Adagrasib. The full list is on the Digoxin page.
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