Drug interactions
Bendroflumethiazide + Glipizide
Severity: Moderate
Bendroflumethiazide and Glipizide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics can raise blood glucose and reduce insulin secretion, which may weaken the glucose-lowering effect of glipizide. Loss of glycemic control can emerge over weeks, particularly at higher thiazide doses or with potassium depletion.
What this interaction means in plain words
Bendroflumethiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Thiazides cause hypokalemia-related impairment of insulin release and may worsen insulin resistance, opposing the sulfonylurea's effect.
What to do
Monitor fasting and post-prandial glucose or HbA1c after starting or adjusting the thiazide, and keep serum potassium normal. Increase the glipizide dose or add other antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide
Frequently asked questions
Can I take Bendroflumethiazide with Glipizide?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Glipizide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics can raise blood glucose and reduce insulin secretion, which may weaken the glucose-lowering effect of glipizide. Loss of glycemic control can emerge over weeks, particularly at higher thiazide doses or with potassium depletion.
How serious is the interaction between Bendroflumethiazide and Glipizide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting and post-prandial glucose or HbA1c after starting or adjusting the thiazide, and keep serum potassium normal. Increase the glipizide dose or add other antidiabetic therapy if control worsens.
What other medicines interact with Glipizide?
MediHelp also lists interactions of Glipizide with, for example, Disopyramide, Fluconazole, Insulin degludec-liraglutide. The full list is on the Glipizide page.
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