Drug interactions
Bendroflumethiazide + Hydrochlorothiazide-irbesartan
Severity: Moderate
Bendroflumethiazide and Hydrochlorothiazide-irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion. Irbesartan partly offsets potassium loss but does not remove the risk.
What this interaction means in plain words
Bendroflumethiazide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of the distal tubular sodium-chloride cotransporter, with increased urinary potassium and sodium loss.
What to do
Avoid concurrent use of two thiazides; stop one agent. If unavoidable, monitor electrolytes and renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrochlorothiazide-irbesartan
- Aliskiren + Hydrochlorothiazide-irbesartan Contraindicated
- Dofetilide + Hydrochlorothiazide-irbesartan Contraindicated
- Hydrochlorothiazide-irbesartan + Sparsentan Contraindicated
- Aldesleukin + Hydrochlorothiazide-irbesartan Major
- Amifostine + Hydrochlorothiazide-irbesartan Major
- Amiloride + Hydrochlorothiazide-irbesartan Major
Frequently asked questions
Can I take Bendroflumethiazide with Hydrochlorothiazide-irbesartan?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Hydrochlorothiazide-irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining two thiazide diuretics duplicates therapy and increases the risk of hypokalemia, hyponatremia, hypomagnesemia and volume depletion. Irbesartan partly offsets potassium loss but does not remove the risk.
How serious is the interaction between Bendroflumethiazide and Hydrochlorothiazide-irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazides; stop one agent. If unavoidable, monitor electrolytes and renal function.
What other medicines interact with Hydrochlorothiazide-irbesartan?
MediHelp also lists interactions of Hydrochlorothiazide-irbesartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-irbesartan page.
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