Drug interactions
Bendroflumethiazide + Metolazone
Severity: Moderate
Bendroflumethiazide and Metolazone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are thiazide-type diuretics, so combining them duplicates therapy and adds to potassium, sodium and magnesium loss. Marked hypokalemia, hyponatremia and volume depletion can occur.
What this interaction means in plain words
Bendroflumethiazide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive inhibition of distal tubule sodium-chloride reabsorption with increased renal potassium excretion.
What to do
Avoid concurrent use of two thiazide-type diuretics; if used, monitor electrolytes, renal function and blood pressure.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metolazone
Frequently asked questions
Can I take Bendroflumethiazide with Metolazone?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Metolazone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both are thiazide-type diuretics, so combining them duplicates therapy and adds to potassium, sodium and magnesium loss. Marked hypokalemia, hyponatremia and volume depletion can occur.
How serious is the interaction between Bendroflumethiazide and Metolazone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two thiazide-type diuretics; if used, monitor electrolytes, renal function and blood pressure.
What other medicines interact with Metolazone?
MediHelp also lists interactions of Metolazone with, for example, Amifostine, Amlodipine-hydrochlorothiazide-valsartan, Amlodipine-olmesartan-hydrochlorothiazide. The full list is on the Metolazone page.
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