Drug interactions
Bendroflumethiazide + Tiotropium-olodaterol
Severity: Moderate
Bendroflumethiazide and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide diuretics lower serum potassium, and beta2-agonists can shift potassium into cells, so low potassium may be more likely. Hypokalemia can promote arrhythmias, particularly in patients with heart disease or hypoxia. The effect is usually modest with inhaled olodaterol at recommended doses.
What this interaction means in plain words
Bendroflumethiazide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypokalemia from renal potassium loss and beta2-mediated intracellular potassium shift.
What to do
Check serum potassium and magnesium periodically, especially in patients with cardiac disease or COPD exacerbations, and replace as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Bendroflumethiazide with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Bendroflumethiazide and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide diuretics lower serum potassium, and beta2-agonists can shift potassium into cells, so low potassium may be more likely. Hypokalemia can promote arrhythmias, particularly in patients with heart disease or hypoxia. The effect is usually modest with inhaled olodaterol at recommended doses.
How serious is the interaction between Bendroflumethiazide and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check serum potassium and magnesium periodically, especially in patients with cardiac disease or COPD exacerbations, and replace as needed.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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