Drug interactions
Benperidol + Mirtazapine
Severity: Moderate
Benperidol and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs cause sedation, so combined use can increase drowsiness and impair psychomotor performance. Benperidol may also prolong the QT interval and mirtazapine has a small additional effect.
What this interaction means in plain words
Benperidol and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from H1 antagonism and antipsychotic sedation, with possible additive QT effects.
What to do
Monitor for sedation, orthostasis and ECG changes in patients with cardiac risk factors. Adjust doses if daytime sedation is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Benperidol with Mirtazapine?
MediHelp rates the interaction as moderate. Benperidol and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs cause sedation, so combined use can increase drowsiness and impair psychomotor performance. Benperidol may also prolong the QT interval and mirtazapine has a small additional effect.
How serious is the interaction between Benperidol and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostasis and ECG changes in patients with cardiac risk factors. Adjust doses if daytime sedation is troublesome.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
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