Drug interactions
Benperidol + Oxycodone
Severity: Moderate
Benperidol and Oxycodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent antipsychotic with sedative and hypotensive properties, and combined use with an opioid can intensify drowsiness, hypotension and respiratory depression. The risk is greatest in elderly or debilitated patients.
What this interaction means in plain words
Benperidol and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and hypotension from dopamine antagonism plus opioid receptor agonism.
What to do
Use the lowest effective doses and monitor for sedation, hypotension and slowed breathing. Reduce the oxycodone dose if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxycodone
- Alvimopan + Oxycodone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Oxycodone Contraindicated
- Isocarboxazid + Oxycodone Contraindicated
- Olanzapine / samidorphan + Oxycodone Contraindicated
- Oxycodone + Phenelzine Contraindicated
- Oxycodone + Sodium oxybate Contraindicated
Frequently asked questions
Can I take Benperidol with Oxycodone?
MediHelp rates the interaction as moderate. Benperidol and Oxycodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent antipsychotic with sedative and hypotensive properties, and combined use with an opioid can intensify drowsiness, hypotension and respiratory depression. The risk is greatest in elderly or debilitated patients.
How serious is the interaction between Benperidol and Oxycodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor for sedation, hypotension and slowed breathing. Reduce the oxycodone dose if excessive sedation occurs.
What other medicines interact with Oxycodone?
MediHelp also lists interactions of Oxycodone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Isocarboxazid. The full list is on the Oxycodone page.
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