Drug interactions
Benperidol + Tiotropium-olodaterol
Severity: Moderate
Benperidol and Tiotropium-olodaterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a butyrophenone antipsychotic that can prolong the QT interval and has some anticholinergic effects, so combined use may add to antimuscarinic burden. Beta2-agonist cardiac stimulation may add to arrhythmia risk in susceptible patients.
What this interaction means in plain words
Benperidol and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antimuscarinic effects and additive QT prolongation with beta2-mediated cardiac effects.
What to do
Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Benperidol with Tiotropium-olodaterol?
MediHelp rates the interaction as moderate. Benperidol and Tiotropium-olodaterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a butyrophenone antipsychotic that can prolong the QT interval and has some anticholinergic effects, so combined use may add to antimuscarinic burden. Beta2-agonist cardiac stimulation may add to arrhythmia risk in susceptible patients.
How serious is the interaction between Benperidol and Tiotropium-olodaterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects and obtain an ECG in patients with cardiac risk factors. Correct potassium and magnesium abnormalities.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
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