Drug interactions
Benperidol + Tramadol
Severity: Moderate
Benperidol and Tramadol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benperidol is a potent butyrophenone antipsychotic that can cause sedation, and tramadol adds opioid CNS depression. Both lower seizure threshold and may cause hypotension. The combination can impair alertness and respiratory drive.
What this interaction means in plain words
Benperidol and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression and additive lowering of seizure threshold.
What to do
Use the lowest effective doses and monitor sedation, respiratory rate and seizure risk. Warn patients about impaired driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benperidol and Tramadol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Tramadol
- Isocarboxazid + Tramadol Contraindicated
- Olanzapine / samidorphan + Tramadol Contraindicated
- Phenelzine + Tramadol Contraindicated
- Procarbazine + Tramadol Contraindicated
- Rasagiline + Tramadol Contraindicated
- Safinamide + Tramadol Contraindicated
Frequently asked questions
Can I take Benperidol with Tramadol?
MediHelp rates the interaction as moderate. Benperidol and Tramadol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benperidol is a potent butyrophenone antipsychotic that can cause sedation, and tramadol adds opioid CNS depression. Both lower seizure threshold and may cause hypotension. The combination can impair alertness and respiratory drive.
How serious is the interaction between Benperidol and Tramadol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation, respiratory rate and seizure risk. Warn patients about impaired driving.
What other medicines interact with Tramadol?
MediHelp also lists interactions of Tramadol with, for example, Isocarboxazid, Olanzapine / samidorphan, Phenelzine. The full list is on the Tramadol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
