Drug interactions
Benzathine penicillin g + Cholera vaccine
Severity: Moderate
Benzathine penicillin g and Cholera vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated cholera vaccine contains a live bacterial strain that may be killed by systemic antibiotics, reducing the immune response. Penicillin G activity against Vibrio cholerae may impair vaccine take.
What this interaction means in plain words
Benzathine penicillin g and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity against the live attenuated vaccine strain reduces replication and immunogenicity.
What to do
Do not give the vaccine to patients who have taken systemic antibiotics within the prior 14 days, per labeling. Delay vaccination until the antibiotic course is finished.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
- Baricitinib + Benzathine penicillin g Minor
Frequently asked questions
Can I take Benzathine penicillin g with Cholera vaccine?
MediHelp rates the interaction as moderate. Benzathine penicillin g and Cholera vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The oral live attenuated cholera vaccine contains a live bacterial strain that may be killed by systemic antibiotics, reducing the immune response. Penicillin G activity against Vibrio cholerae may impair vaccine take.
How serious is the interaction between Benzathine penicillin g and Cholera vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give the vaccine to patients who have taken systemic antibiotics within the prior 14 days, per labeling. Delay vaccination until the antibiotic course is finished.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Microbiota, Omadacycline, Sodium picosulfate / magnesium oxide / anhydrous citric acid. The full list is on the Benzathine penicillin g page.
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