Drug interactions
Benzathine penicillin g + Microbiota
Severity: Moderate
Benzathine penicillin g and Microbiota: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral microbiota products contain live bacterial spores intended to recolonize the gut. Concurrent penicillin can act against them and reduce engraftment and effectiveness, although benzathine penicillin has a prolonged presence after injection.
What this interaction means in plain words
Benzathine penicillin g and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity of penicillin against the live microbiota components reduces colonization (pharmacodynamic antagonism).
What to do
Complete antibiotic therapy and wait at least 2 to 4 days before giving oral microbiota. Because benzathine penicillin persists for weeks, consider timing the product with this in mind.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Omadacycline Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
- Baricitinib + Benzathine penicillin g Minor
Frequently asked questions
Can I take Benzathine penicillin g with Microbiota?
MediHelp rates the interaction as moderate. Benzathine penicillin g and Microbiota can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral microbiota products contain live bacterial spores intended to recolonize the gut. Concurrent penicillin can act against them and reduce engraftment and effectiveness, although benzathine penicillin has a prolonged presence after injection.
How serious is the interaction between Benzathine penicillin g and Microbiota?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Complete antibiotic therapy and wait at least 2 to 4 days before giving oral microbiota. Because benzathine penicillin persists for weeks, consider timing the product with this in mind.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Omadacycline, Sodium picosulfate / magnesium oxide / anhydrous citric acid. The full list is on the Benzathine penicillin g page.
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