Drug interactions
Benzathine penicillin g + Omadacycline
Severity: Moderate
Benzathine penicillin g and Omadacycline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bacteriostatic tetracyclines may blunt the bactericidal effect of penicillins, which require actively growing bacteria. The clinical importance is uncertain and mostly supported by in vitro data and older reports.
What this interaction means in plain words
Benzathine penicillin g and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Benzathine penicillin g belongs to Anti Bacterial; Omadacycline belongs to Anti Bacterial.
Why it happens
Tetracycline-induced inhibition of bacterial protein synthesis and growth reduces the activity of cell-wall-active beta-lactams.
What to do
Avoid the combination for serious infections where bactericidal activity is needed. If both are required, monitor clinical response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Benzathine penicillin g
- Benzathine penicillin g + Cholera vaccine Moderate
- Benzathine penicillin g + Microbiota Moderate
- Benzathine penicillin g + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Benzathine penicillin g + Vadadustat Moderate
- Amifampridine + Benzathine penicillin g Minor
- Baricitinib + Benzathine penicillin g Minor
Other interactions of Omadacycline
- Acitretin + Omadacycline Contraindicated
- Isotretinoin + Omadacycline Major
- Omadacycline + Tretinoin Major
- Aluminum hydroxide + Omadacycline Moderate
- Amoxicillin-clavulanic acid + Omadacycline Moderate
- Amoxicillin + Omadacycline Moderate
Frequently asked questions
Can I take Benzathine penicillin g with Omadacycline?
MediHelp rates the interaction as moderate. Benzathine penicillin g and Omadacycline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bacteriostatic tetracyclines may blunt the bactericidal effect of penicillins, which require actively growing bacteria. The clinical importance is uncertain and mostly supported by in vitro data and older reports.
How serious is the interaction between Benzathine penicillin g and Omadacycline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination for serious infections where bactericidal activity is needed. If both are required, monitor clinical response.
What other medicines interact with Benzathine penicillin g?
MediHelp also lists interactions of Benzathine penicillin g with, for example, Cholera vaccine, Microbiota, Sodium picosulfate / magnesium oxide / anhydrous citric acid. The full list is on the Benzathine penicillin g page.
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