Drug interactions
Benzhydrocodone / acetaminophen + Chloroquine
Severity: Minor
Benzhydrocodone / acetaminophen and Chloroquine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chloroquine may inhibit CYP2D6, which converts hydrocodone to hydromorphone, so analgesia could be slightly reduced while hydrocodone exposure rises. The change is generally modest, but additive CNS effects of opioid should be considered.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Chloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2D6 inhibition by chloroquine alters hydrocodone metabolism.
What to do
No routine adjustment; monitor analgesic response and sedation or respiratory depression.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Chloroquine
- Chloroquine + Cisapride Contraindicated
- Chloroquine + Dofetilide Contraindicated
- Chloroquine + Dronedarone Contraindicated
- Chloroquine + Droperidol Contraindicated
- Chloroquine + Panobinostat Contraindicated
- Chloroquine + Pimozide Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Chloroquine?
MediHelp rates the interaction as minor. Benzhydrocodone / acetaminophen and Chloroquine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chloroquine may inhibit CYP2D6, which converts hydrocodone to hydromorphone, so analgesia could be slightly reduced while hydrocodone exposure rises. The change is generally modest, but additive CNS effects of opioid should be considered.
How serious is the interaction between Benzhydrocodone / acetaminophen and Chloroquine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor analgesic response and sedation or respiratory depression.
What other medicines interact with Chloroquine?
MediHelp also lists interactions of Chloroquine with, for example, Cisapride, Dofetilide, Dronedarone. The full list is on the Chloroquine page.
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