Drug interactions
Benzhydrocodone / acetaminophen + Eletriptan
Severity: Moderate
Benzhydrocodone / acetaminophen and Eletriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids and triptans both act on the serotonergic system, and serotonin syndrome has been reported with the combination. Hydrocodone has a low serotonergic potential, so the risk is considered small.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible additive serotonergic effects.
What to do
If combined, monitor for agitation, clonus, hyperthermia and autonomic instability, especially at initiation or dose increases. Stop one or both drugs if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Eletriptan
- Almotriptan + Eletriptan Contraindicated
- Atazanavir + Eletriptan Contraindicated
- Ceritinib + Eletriptan Contraindicated
- Clarithromycin + Eletriptan Contraindicated
- Cobicistat + Eletriptan Contraindicated
- Conivaptan + Eletriptan Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Eletriptan?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Eletriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Opioids and triptans both act on the serotonergic system, and serotonin syndrome has been reported with the combination. Hydrocodone has a low serotonergic potential, so the risk is considered small.
How serious is the interaction between Benzhydrocodone / acetaminophen and Eletriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If combined, monitor for agitation, clonus, hyperthermia and autonomic instability, especially at initiation or dose increases. Stop one or both drugs if serotonin syndrome is suspected.
What other medicines interact with Eletriptan?
MediHelp also lists interactions of Eletriptan with, for example, Almotriptan, Atazanavir, Ceritinib. The full list is on the Eletriptan page.
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