Drug interactions
Benzhydrocodone / acetaminophen + Loratadine
Severity: Minor
Benzhydrocodone / acetaminophen and Loratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids such as benzhydrocodone cause sedation and respiratory depression, and other drugs with CNS effects may add to this. Loratadine is minimally sedating, so the added risk is modest.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive CNS depression.
What to do
Monitor for sedation and respiratory depression, especially at opioid initiation or dose increases.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Loratadine
- Acrivastine + Loratadine Moderate
- Amobarbital + Loratadine Moderate
- Fentanyl + Loratadine Moderate
- Isocarboxazid + Loratadine Moderate
- Levoketoconazole + Loratadine Moderate
- Loratadine + Mavacamten Moderate
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Loratadine?
MediHelp rates the interaction as minor. Benzhydrocodone / acetaminophen and Loratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Opioids such as benzhydrocodone cause sedation and respiratory depression, and other drugs with CNS effects may add to this. Loratadine is minimally sedating, so the added risk is modest.
How serious is the interaction between Benzhydrocodone / acetaminophen and Loratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression, especially at opioid initiation or dose increases.
What other medicines interact with Loratadine?
MediHelp also lists interactions of Loratadine with, for example, Acrivastine, Amobarbital, Fentanyl. The full list is on the Loratadine page.
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