Drug interactions
Benzhydrocodone / acetaminophen + Methamphetamine
Severity: Moderate
Benzhydrocodone / acetaminophen and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzhydrocodone is an opioid prodrug of hydrocodone, and amphetamines have serotonergic activity. Taken together there is a possible risk of serotonin syndrome with agitation, tremor, hyperthermia, clonus and autonomic instability. Stimulant effects may also mask opioid sedation.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive serotonergic activity, with amphetamine-mediated monoamine release combined with opioid effects on serotonin neurotransmission.
What to do
Watch for signs of serotonin toxicity, especially at initiation and after dose changes. Stop one or both agents if symptoms of serotonin syndrome appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Methamphetamine?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzhydrocodone is an opioid prodrug of hydrocodone, and amphetamines have serotonergic activity. Taken together there is a possible risk of serotonin syndrome with agitation, tremor, hyperthermia, clonus and autonomic instability. Stimulant effects may also mask opioid sedation.
How serious is the interaction between Benzhydrocodone / acetaminophen and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Watch for signs of serotonin toxicity, especially at initiation and after dose changes. Stop one or both agents if symptoms of serotonin syndrome appear.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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