Drug interactions
Benzhydrocodone / acetaminophen + Nevirapine
Severity: Major
Benzhydrocodone / acetaminophen and Nevirapine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nevirapine induces CYP3A4 and may lower hydrocodone concentrations, causing reduced analgesia or withdrawal in dependent patients. If nevirapine is stopped, hydrocodone levels can rise and cause serious respiratory depression.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Nevirapine induces CYP3A4, increasing hydrocodone clearance, with reversal on inducer withdrawal.
What to do
Monitor analgesia and withdrawal signs when starting nevirapine. If nevirapine is discontinued, reduce the opioid dose and monitor for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nevirapine
- Elbasvir / grazoprevir + Nevirapine Contraindicated
- Nevirapine + Ranolazine Contraindicated
- Nevirapine + St john's wort Contraindicated
- Abemaciclib + Nevirapine Major
- Acalabrutinib + Nevirapine Major
- Amobarbital + Nevirapine Major
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Nevirapine?
MediHelp rates the interaction as major. Benzhydrocodone / acetaminophen and Nevirapine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nevirapine induces CYP3A4 and may lower hydrocodone concentrations, causing reduced analgesia or withdrawal in dependent patients. If nevirapine is stopped, hydrocodone levels can rise and cause serious respiratory depression.
How serious is the interaction between Benzhydrocodone / acetaminophen and Nevirapine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor analgesia and withdrawal signs when starting nevirapine. If nevirapine is discontinued, reduce the opioid dose and monitor for sedation and respiratory depression.
What other medicines interact with Nevirapine?
MediHelp also lists interactions of Nevirapine with, for example, Elbasvir / grazoprevir, Ranolazine, St john's wort. The full list is on the Nevirapine page.
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