Drug interactions
Benzhydrocodone / acetaminophen + Ranolazine
Severity: Minor
Benzhydrocodone / acetaminophen and Ranolazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ranolazine weakly inhibits CYP2D6, which converts hydrocodone to hydromorphone. The effect on analgesia or opioid toxicity is likely small, and hydrocodone is mainly cleared by CYP3A4.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP2D6 inhibition by ranolazine altering hydrocodone conversion to hydromorphone.
What to do
No adjustment is usually needed; monitor analgesic response and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ranolazine
- Adagrasib + Ranolazine Contraindicated
- Amobarbital + Ranolazine Contraindicated
- Apalutamide + Ranolazine Contraindicated
- Butabarbital + Ranolazine Contraindicated
- Carbamazepine + Ranolazine Contraindicated
- Clarithromycin + Ranolazine Contraindicated
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Ranolazine?
MediHelp rates the interaction as minor. Benzhydrocodone / acetaminophen and Ranolazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ranolazine weakly inhibits CYP2D6, which converts hydrocodone to hydromorphone. The effect on analgesia or opioid toxicity is likely small, and hydrocodone is mainly cleared by CYP3A4.
How serious is the interaction between Benzhydrocodone / acetaminophen and Ranolazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is usually needed; monitor analgesic response and sedation.
What other medicines interact with Ranolazine?
MediHelp also lists interactions of Ranolazine with, for example, Adagrasib, Amobarbital, Apalutamide. The full list is on the Ranolazine page.
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