Drug interactions
Benzhydrocodone / acetaminophen + Vigabatrin
Severity: Moderate
Benzhydrocodone / acetaminophen and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The opioid component adds CNS and respiratory depression to the sedation caused by vigabatrin. This may impair alertness and breathing, especially at the start of treatment or with dose increases.
What this interaction means in plain words
Benzhydrocodone / acetaminophen and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression from opioid and vigabatrin.
What to do
Use the lowest effective opioid dose for the shortest duration and monitor sedation and respiratory rate. Warn patients against driving and alcohol use.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
- Buprenorphine long-acting + Vigabatrin Moderate
Frequently asked questions
Can I take Benzhydrocodone / acetaminophen with Vigabatrin?
MediHelp rates the interaction as moderate. Benzhydrocodone / acetaminophen and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The opioid component adds CNS and respiratory depression to the sedation caused by vigabatrin. This may impair alertness and breathing, especially at the start of treatment or with dose increases.
How serious is the interaction between Benzhydrocodone / acetaminophen and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective opioid dose for the shortest duration and monitor sedation and respiratory rate. Warn patients against driving and alcohol use.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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