Drug interactions
Buprenorphine long-acting + Vigabatrin
Severity: Moderate
Buprenorphine long-acting and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vigabatrin causes somnolence in many patients, and long-acting injectable buprenorphine adds opioid-related sedation and a risk of respiratory depression. Because the injectable depot cannot be quickly withdrawn, additive effects may be prolonged.
What this interaction means in plain words
Buprenorphine long-acting and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive central nervous system depression through pharmacodynamic effects.
What to do
Monitor for sedation and respiratory depression after injection and with any change in vigabatrin dose. Counsel the patient on avoiding driving until the combined effect is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Buprenorphine long-acting and Vigabatrin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
Frequently asked questions
Can I take Buprenorphine long-acting with Vigabatrin?
MediHelp rates the interaction as moderate. Buprenorphine long-acting and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vigabatrin causes somnolence in many patients, and long-acting injectable buprenorphine adds opioid-related sedation and a risk of respiratory depression. Because the injectable depot cannot be quickly withdrawn, additive effects may be prolonged.
How serious is the interaction between Buprenorphine long-acting and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and respiratory depression after injection and with any change in vigabatrin dose. Counsel the patient on avoiding driving until the combined effect is known.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
