Drug interactions
Brexanolone + Vigabatrin
Severity: Moderate
Brexanolone and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Brexanolone causes dose-related sedation and sudden loss of consciousness, and vigabatrin adds somnolence. The combination may increase the risk of excessive sedation.
What this interaction means in plain words
Brexanolone and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression through GABAergic effects.
What to do
Monitor sedation level and oxygen saturation continuously during the brexanolone infusion. Reduce or interrupt the infusion if excessive sedation occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Buprenorphine long-acting + Vigabatrin Moderate
Frequently asked questions
Can I take Brexanolone with Vigabatrin?
MediHelp rates the interaction as moderate. Brexanolone and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Brexanolone causes dose-related sedation and sudden loss of consciousness, and vigabatrin adds somnolence. The combination may increase the risk of excessive sedation.
How serious is the interaction between Brexanolone and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and oxygen saturation continuously during the brexanolone infusion. Reduce or interrupt the infusion if excessive sedation occurs.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
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