Drug interactions
Avapritinib + Vigabatrin
Severity: Moderate
Avapritinib and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause somnolence and cognitive effects, and avapritinib is associated with cognitive impairment and intracranial hemorrhage. Together they may increase drowsiness and confusion.
What this interaction means in plain words
Avapritinib and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Avapritinib belongs to Oncology; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive CNS effects.
What to do
Monitor cognition and sedation, and reduce doses if impairment develops. Advise patients against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Avapritinib and Vigabatrin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Asenapine + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
- Buprenorphine long-acting + Vigabatrin Moderate
Other interactions of Avapritinib
Frequently asked questions
Can I take Avapritinib with Vigabatrin?
MediHelp rates the interaction as moderate. Avapritinib and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause somnolence and cognitive effects, and avapritinib is associated with cognitive impairment and intracranial hemorrhage. Together they may increase drowsiness and confusion.
How serious is the interaction between Avapritinib and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor cognition and sedation, and reduce doses if impairment develops. Advise patients against driving until the response is known.
What other medicines interact with Vigabatrin?
MediHelp also lists interactions of Vigabatrin with, for example, Amisulpride, Asenapine transdermal, Asenapine. The full list is on the Vigabatrin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
