Drug interactions
Asenapine + Vigabatrin
Severity: Moderate
Asenapine and Vigabatrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vigabatrin commonly causes somnolence and fatigue, and asenapine adds further sedation, so combined use may increase drowsiness and impair alertness. Vigabatrin can also cause mood and behavioural changes that may complicate psychiatric treatment.
What this interaction means in plain words
Asenapine and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Asenapine belongs to Central Nervous System; Vigabatrin belongs to Central Nervous System.
Why it happens
Additive central nervous system depression (pharmacodynamic).
What to do
Monitor for sedation and psychiatric symptoms, and counsel patients about driving and machinery. Adjust doses if daytime impairment develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Asenapine
- Asenapine + Pimozide Contraindicated
- Asenapine + Thioridazine Contraindicated
- Asenapine + Vandetanib Contraindicated
- Adagrasib + Asenapine Major
- Alfentanil + Asenapine Major
- Alfuzosin + Asenapine Major
Other interactions of Vigabatrin
- Amisulpride + Vigabatrin Moderate
- Asenapine transdermal + Vigabatrin Moderate
- Avapritinib + Vigabatrin Moderate
- Benzhydrocodone / acetaminophen + Vigabatrin Moderate
- Brexanolone + Vigabatrin Moderate
- Buprenorphine long-acting + Vigabatrin Moderate
Frequently asked questions
Can I take Asenapine with Vigabatrin?
MediHelp rates the interaction as moderate. Asenapine and Vigabatrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vigabatrin commonly causes somnolence and fatigue, and asenapine adds further sedation, so combined use may increase drowsiness and impair alertness. Vigabatrin can also cause mood and behavioural changes that may complicate psychiatric treatment.
How serious is the interaction between Asenapine and Vigabatrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and psychiatric symptoms, and counsel patients about driving and machinery. Adjust doses if daytime impairment develops.
What other medicines interact with Asenapine?
MediHelp also lists interactions of Asenapine with, for example, Pimozide, Thioridazine, Vandetanib. The full list is on the Asenapine page.
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