Drug interactions
Benzphetamine + Ergotamine
Severity: Major
Benzphetamine and Ergotamine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic that raises blood pressure and causes vasoconstriction. Combined with ergotamine, additive vasoconstriction may cause hypertension and ischemia.
What this interaction means in plain words
Benzphetamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive vasoconstrictor and pressor effects (sympathomimetic plus ergot).
What to do
Avoid concurrent use and choose alternative therapy; monitor blood pressure and limb perfusion if unavoidable.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ergotamine
- Almotriptan + Ergotamine Contraindicated
- Atazanavir + Ergotamine Contraindicated
- Clarithromycin + Ergotamine Contraindicated
- Cobicistat + Ergotamine Contraindicated
- Darunavir + Ergotamine Contraindicated
- Dihydroergotamine intranasal + Ergotamine Contraindicated
Frequently asked questions
Can I take Benzphetamine with Ergotamine?
MediHelp rates the interaction as major. Benzphetamine and Ergotamine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Benzphetamine is a sympathomimetic anorectic that raises blood pressure and causes vasoconstriction. Combined with ergotamine, additive vasoconstriction may cause hypertension and ischemia.
How serious is the interaction between Benzphetamine and Ergotamine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and choose alternative therapy; monitor blood pressure and limb perfusion if unavoidable.
What other medicines interact with Ergotamine?
MediHelp also lists interactions of Ergotamine with, for example, Almotriptan, Atazanavir, Clarithromycin. The full list is on the Ergotamine page.
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