Drug interactions
Benzphetamine + Methamphetamine
Severity: Moderate
Benzphetamine and Methamphetamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are sympathomimetic amines with stimulant effects. Used together they produce additive increases in blood pressure and heart rate and can cause insomnia, agitation and arrhythmia. Combining two anorectic stimulants has no therapeutic rationale.
What this interaction means in plain words
Benzphetamine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic sympathomimetic effects through release of norepinephrine and dopamine.
What to do
Avoid concurrent use of two sympathomimetic anorectics or stimulants. If unavoidable, monitor blood pressure, heart rate and cardiac symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methamphetamine
- Isocarboxazid + Methamphetamine Contraindicated
- Linezolid + Methamphetamine Contraindicated
- Methamphetamine + Phenelzine Contraindicated
- Methamphetamine + Procarbazine Contraindicated
- Methamphetamine + Rasagiline Contraindicated
- Methamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Benzphetamine with Methamphetamine?
MediHelp rates the interaction as moderate. Benzphetamine and Methamphetamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are sympathomimetic amines with stimulant effects. Used together they produce additive increases in blood pressure and heart rate and can cause insomnia, agitation and arrhythmia. Combining two anorectic stimulants has no therapeutic rationale.
How serious is the interaction between Benzphetamine and Methamphetamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two sympathomimetic anorectics or stimulants. If unavoidable, monitor blood pressure, heart rate and cardiac symptoms.
What other medicines interact with Methamphetamine?
MediHelp also lists interactions of Methamphetamine with, for example, Isocarboxazid, Linezolid, Phenelzine. The full list is on the Methamphetamine page.
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