Drug interactions
Benzphetamine + Midodrine
Severity: Moderate
Benzphetamine and Midodrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic amine, so with midodrine the pressor effects add together. This may produce hypertension, reflex bradycardia or tachyarrhythmia, especially in those with cardiovascular disease.
What this interaction means in plain words
Benzphetamine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive adrenergic stimulation from alpha-1 agonism and indirect sympathomimetic release of catecholamines.
What to do
Monitor blood pressure and heart rate. Avoid the combination in uncontrolled hypertension or significant heart disease.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midodrine
- Isocarboxazid + Midodrine Contraindicated
- Midodrine + Phenelzine Contraindicated
- Midodrine + Tranylcypromine Contraindicated
- Dextroamphetamine + Midodrine Major
- Dihydroergotamine intranasal + Midodrine Major
- Dihydroergotamine + Midodrine Major
Frequently asked questions
Can I take Benzphetamine with Midodrine?
MediHelp rates the interaction as moderate. Benzphetamine and Midodrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic amine, so with midodrine the pressor effects add together. This may produce hypertension, reflex bradycardia or tachyarrhythmia, especially in those with cardiovascular disease.
How serious is the interaction between Benzphetamine and Midodrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate. Avoid the combination in uncontrolled hypertension or significant heart disease.
What other medicines interact with Midodrine?
MediHelp also lists interactions of Midodrine with, for example, Isocarboxazid, Phenelzine, Tranylcypromine. The full list is on the Midodrine page.
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