Drug interactions
Benzphetamine + Mirtazapine
Severity: Moderate
Benzphetamine and Mirtazapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic whose stimulant effects may partly counter mirtazapine sedation. Combining serotonergic and noradrenergic agents may also raise blood pressure or cause agitation, but the clinical effect is unpredictable.
What this interaction means in plain words
Benzphetamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Opposing CNS stimulant and sedative effects with overlapping monoaminergic activity; the net effect is not well established.
What to do
Monitor blood pressure, heart rate, sleep and mood after starting the combination. Reassess the need for benzphetamine if agitation or hypertension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Benzphetamine and Mirtazapine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Mirtazapine
- Isocarboxazid + Mirtazapine Contraindicated
- Mirtazapine + Phenelzine Contraindicated
- Mirtazapine + Pimozide Contraindicated
- Mirtazapine + Procarbazine Contraindicated
- Mirtazapine + Rasagiline Contraindicated
- Mirtazapine + Selegiline Contraindicated
Frequently asked questions
Can I take Benzphetamine with Mirtazapine?
MediHelp rates the interaction as moderate. Benzphetamine and Mirtazapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic whose stimulant effects may partly counter mirtazapine sedation. Combining serotonergic and noradrenergic agents may also raise blood pressure or cause agitation, but the clinical effect is unpredictable.
How serious is the interaction between Benzphetamine and Mirtazapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate, sleep and mood after starting the combination. Reassess the need for benzphetamine if agitation or hypertension occurs.
What other medicines interact with Mirtazapine?
MediHelp also lists interactions of Mirtazapine with, for example, Isocarboxazid, Phenelzine, Pimozide. The full list is on the Mirtazapine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
