Drug interactions
Benzphetamine + Trazodone
Severity: Moderate
Benzphetamine and Trazodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Benzphetamine is a sympathomimetic anorectic, and trazodone has alpha-adrenergic blocking and serotonergic effects. Together they may unpredictably alter blood pressure and heart rate, and the anorectic may reduce or increase the effect of the antidepressant. The clinical significance is generally modest.
What this interaction means in plain words
Benzphetamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Pharmacodynamic opposition and overlap at adrenergic and monoaminergic pathways; the mechanism is not firmly established for trazodone.
What to do
Monitor blood pressure, heart rate and mood or anxiety symptoms when the two are combined. Consider a non-stimulant weight-loss approach if cardiovascular effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trazodone
- Arsenic trioxide + Trazodone Contraindicated
- Ibutilide + Trazodone Contraindicated
- Isocarboxazid + Trazodone Contraindicated
- Levoketoconazole + Trazodone Contraindicated
- Methylene blue + Trazodone Contraindicated
- Phenelzine + Trazodone Contraindicated
Frequently asked questions
Can I take Benzphetamine with Trazodone?
MediHelp rates the interaction as moderate. Benzphetamine and Trazodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Benzphetamine is a sympathomimetic anorectic, and trazodone has alpha-adrenergic blocking and serotonergic effects. Together they may unpredictably alter blood pressure and heart rate, and the anorectic may reduce or increase the effect of the antidepressant. The clinical significance is generally modest.
How serious is the interaction between Benzphetamine and Trazodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and mood or anxiety symptoms when the two are combined. Consider a non-stimulant weight-loss approach if cardiovascular effects emerge.
What other medicines interact with Trazodone?
MediHelp also lists interactions of Trazodone with, for example, Arsenic trioxide, Ibutilide, Isocarboxazid. The full list is on the Trazodone page.
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