Drug interactions
Berotralstat + Carbamazepine
Severity: Moderate
Berotralstat and Carbamazepine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits CYP3A4 and may raise carbamazepine levels, risking dizziness, ataxia, diplopia and other toxicity. Carbamazepine, as a P-gp and CYP3A inducer, may also lower berotralstat exposure and reduce its prophylactic efficacy.
What this interaction means in plain words
Berotralstat and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Carbamazepine belongs to Central Nervous System.
Why it happens
Berotralstat inhibits CYP3A4 while carbamazepine induces CYP3A4 and P-glycoprotein, so each alters the other's exposure.
What to do
Monitor carbamazepine serum concentrations and signs of toxicity, and adjust the dose as needed. Monitor hereditary angioedema attack frequency for loss of berotralstat efficacy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carbamazepine
- Artemether / lumefantrine + Carbamazepine Contraindicated
- Cabotegravir + Carbamazepine Contraindicated
- Carbamazepine + Delamanid Contraindicated
- Carbamazepine + Dienogest / estradiol valerate Contraindicated
- Carbamazepine + Doravirine Contraindicated
- Carbamazepine + Elbasvir / grazoprevir Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Carbamazepine?
MediHelp rates the interaction as moderate. Berotralstat and Carbamazepine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits CYP3A4 and may raise carbamazepine levels, risking dizziness, ataxia, diplopia and other toxicity. Carbamazepine, as a P-gp and CYP3A inducer, may also lower berotralstat exposure and reduce its prophylactic efficacy.
How serious is the interaction between Berotralstat and Carbamazepine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor carbamazepine serum concentrations and signs of toxicity, and adjust the dose as needed. Monitor hereditary angioedema attack frequency for loss of berotralstat efficacy.
What other medicines interact with Carbamazepine?
MediHelp also lists interactions of Carbamazepine with, for example, Artemether / lumefantrine, Cabotegravir, Delamanid. The full list is on the Carbamazepine page.
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