Drug interactions
Berotralstat + Carfilzomib
Severity: Minor
Berotralstat and Carfilzomib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-glycoprotein and could raise exposure to P-gp substrates. Carfilzomib is cleared mainly by peptidase metabolism, so any increase is expected to be small and its clinical importance is uncertain.
What this interaction means in plain words
Berotralstat and Carfilzomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Berotralstat belongs to Miscellaneous; Carfilzomib belongs to Oncology.
Why it happens
Berotralstat inhibits intestinal and cellular P-gp efflux, which may modestly increase carfilzomib exposure.
What to do
No dose change is normally needed; monitor for carfilzomib toxicity such as cardiopulmonary effects, cytopenias and renal function during coadministration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carfilzomib
- Carfilzomib + Etrasimod Major
- Carfilzomib + Ropeginterferon alfa 2b Major
- Carfilzomib + Dichlorphenamide Moderate
- Carfilzomib + Palifermin Moderate
- Carfilzomib + Ponesimod Moderate
- Carfilzomib + Siponimod Moderate
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Carfilzomib?
MediHelp rates the interaction as minor. Berotralstat and Carfilzomib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Berotralstat inhibits P-glycoprotein and could raise exposure to P-gp substrates. Carfilzomib is cleared mainly by peptidase metabolism, so any increase is expected to be small and its clinical importance is uncertain.
How serious is the interaction between Berotralstat and Carfilzomib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is normally needed; monitor for carfilzomib toxicity such as cardiopulmonary effects, cytopenias and renal function during coadministration.
What other medicines interact with Carfilzomib?
MediHelp also lists interactions of Carfilzomib with, for example, Etrasimod, Ropeginterferon alfa 2b, Dichlorphenamide. The full list is on the Carfilzomib page.
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