Drug interactions
Bosutinib + Desloratadine
Severity: Minor
Bosutinib and Desloratadine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bosutinib inhibits P-glycoprotein and may modestly increase desloratadine exposure. The clinical consequence is probably small given desloratadine's broad safety margin.
What this interaction means in plain words
Bosutinib and Desloratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Bosutinib belongs to Oncology; Desloratadine belongs to Respiratory.
Why it happens
P-glycoprotein inhibition by bosutinib reducing desloratadine efflux.
What to do
No dose adjustment is usually required; monitor for increased antihistamine adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Desloratadine
- Desloratadine + Erdafitinib Moderate
- Desloratadine + Isocarboxazid Moderate
- Desloratadine + Tranylcypromine Moderate
- Desloratadine + Zuranolone Moderate
- Amifampridine + Desloratadine Minor
- Berotralstat + Desloratadine Minor
Other interactions of Bosutinib
- Amiodarone + Bosutinib Major
- Apalutamide + Bosutinib Major
- Aprepitant + Bosutinib Major
- Bosentan + Bosutinib Major
- Bosutinib + Carbamazepine Major
- Bosutinib + Chlorpromazine Major
Frequently asked questions
Can I take Bosutinib with Desloratadine?
MediHelp rates the interaction as minor. Bosutinib and Desloratadine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Bosutinib inhibits P-glycoprotein and may modestly increase desloratadine exposure. The clinical consequence is probably small given desloratadine's broad safety margin.
How serious is the interaction between Bosutinib and Desloratadine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for increased antihistamine adverse effects.
What other medicines interact with Desloratadine?
MediHelp also lists interactions of Desloratadine with, for example, Erdafitinib, Isocarboxazid, Tranylcypromine. The full list is on the Desloratadine page.
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