Drug interactions
Berotralstat + Etonogestrel
Severity: Moderate
Berotralstat and Etonogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat can raise etonogestrel concentrations, which may increase progestogenic adverse effects. The contraceptive effect is not expected to be reduced.
What this interaction means in plain words
Berotralstat and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Etonogestrel belongs to Endocrine.
Why it happens
Inhibition of CYP3A4 or transporters by berotralstat reduces etonogestrel clearance.
What to do
Weigh benefits and risks and monitor for progestogenic adverse effects such as bleeding changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Other interactions of Etonogestrel
Frequently asked questions
Can I take Berotralstat with Etonogestrel?
MediHelp rates the interaction as moderate. Berotralstat and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat can raise etonogestrel concentrations, which may increase progestogenic adverse effects. The contraceptive effect is not expected to be reduced.
How serious is the interaction between Berotralstat and Etonogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Weigh benefits and risks and monitor for progestogenic adverse effects such as bleeding changes.
What other medicines interact with Berotralstat?
MediHelp also lists interactions of Berotralstat with, for example, Ergotamine, Nilotinib, Pimozide. The full list is on the Berotralstat page.
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