Drug interactions
Berotralstat + Flibanserin
Severity: Moderate
Berotralstat and Flibanserin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Flibanserin may inhibit intestinal P-glycoprotein and so could raise berotralstat exposure, with potential for more gastrointestinal effects or QT prolongation at higher exposure.
What this interaction means in plain words
Berotralstat and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Flibanserin belongs to Genitourinary.
Why it happens
Inhibition of P-glycoprotein efflux increases berotralstat absorption.
What to do
Monitor for gastrointestinal adverse effects and consider ECG monitoring in patients with QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Flibanserin
- Atazanavir + Flibanserin Contraindicated
- Ceritinib + Flibanserin Contraindicated
- Clarithromycin + Flibanserin Contraindicated
- Cobicistat + Flibanserin Contraindicated
- Conivaptan + Flibanserin Contraindicated
- Crizotinib + Flibanserin Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Flibanserin?
MediHelp rates the interaction as moderate. Berotralstat and Flibanserin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Flibanserin may inhibit intestinal P-glycoprotein and so could raise berotralstat exposure, with potential for more gastrointestinal effects or QT prolongation at higher exposure.
How serious is the interaction between Berotralstat and Flibanserin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal adverse effects and consider ECG monitoring in patients with QT risk factors.
What other medicines interact with Flibanserin?
MediHelp also lists interactions of Flibanserin with, for example, Atazanavir, Ceritinib, Clarithromycin. The full list is on the Flibanserin page.
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