Drug interactions
Berotralstat + Loperamide
Severity: Moderate
Berotralstat and Loperamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-gp, which normally limits loperamide absorption and brain penetration. Higher loperamide exposure may increase constipation, CNS effects and cardiac toxicity, and berotralstat itself can prolong the QT interval.
What this interaction means in plain words
Berotralstat and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Loperamide belongs to Gastrointestinal Tract.
Why it happens
P-gp inhibition by berotralstat increases systemic loperamide exposure.
What to do
Use the lowest effective loperamide dose and avoid exceeding labeled limits. Monitor for constipation, drowsiness and palpitations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Loperamide
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Loperamide?
MediHelp rates the interaction as moderate. Berotralstat and Loperamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-gp, which normally limits loperamide absorption and brain penetration. Higher loperamide exposure may increase constipation, CNS effects and cardiac toxicity, and berotralstat itself can prolong the QT interval.
How serious is the interaction between Berotralstat and Loperamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective loperamide dose and avoid exceeding labeled limits. Monitor for constipation, drowsiness and palpitations.
What other medicines interact with Loperamide?
MediHelp also lists interactions of Loperamide with, for example, Amiodarone, Amisulpride, Anagrelide. The full list is on the Loperamide page.
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