Drug interactions
Berotralstat + Lovastatin
Severity: Moderate
Berotralstat and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits P-gp and BCRP and also CYP3A4 to a modest degree. Lovastatin exposure may therefore increase, raising the risk of myopathy.
What this interaction means in plain words
Berotralstat and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Lovastatin belongs to Cardiovascular.
Why it happens
Berotralstat inhibits P-gp and CYP3A4, which may increase lovastatin exposure.
What to do
Use the lowest effective lovastatin dose and monitor for muscle pain or weakness. Check CK if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Lovastatin?
MediHelp rates the interaction as moderate. Berotralstat and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits P-gp and BCRP and also CYP3A4 to a modest degree. Lovastatin exposure may therefore increase, raising the risk of myopathy.
How serious is the interaction between Berotralstat and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective lovastatin dose and monitor for muscle pain or weakness. Check CK if symptoms occur.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
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