Drug interactions
Berotralstat + Midazolam
Severity: Moderate
Berotralstat and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Berotralstat inhibits CYP3A4 and may raise midazolam concentrations, deepening and prolonging sedation. Midazolam is a sensitive CYP3A4 substrate, so oral dosing is particularly affected.
What this interaction means in plain words
Berotralstat and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Berotralstat belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Why it happens
Inhibition of CYP3A4-mediated midazolam metabolism by berotralstat.
What to do
Monitor sedation and respiratory function, and reduce the midazolam dose, especially with oral use. Use extra caution for procedural sedation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Berotralstat
- Berotralstat + Ergotamine Major
- Berotralstat + Nilotinib Major
- Berotralstat + Pimozide Major
- Berotralstat + Quinidine Major
- Berotralstat + Quinine Major
- Berotralstat + Tacrolimus Major
Frequently asked questions
Can I take Berotralstat with Midazolam?
MediHelp rates the interaction as moderate. Berotralstat and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Berotralstat inhibits CYP3A4 and may raise midazolam concentrations, deepening and prolonging sedation. Midazolam is a sensitive CYP3A4 substrate, so oral dosing is particularly affected.
How serious is the interaction between Berotralstat and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory function, and reduce the midazolam dose, especially with oral use. Use extra caution for procedural sedation.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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